You can do this by excluding them when you create a report initially or after the report is created by editing the report.
Reference the "Creating a Report" article to learn how to create reports from scratch. Pay close attention to the Filters section of the report and you will see the option to exclude personnel.
If you have a report created already, reference the "Modify a Report" article to learn how to make changes to the filters of the report.
NOTE: In each report section, there is a check box labeled "Prompt for this Setting each time the Report is Run?" If you want to be able to exclude certain personnel each time your run that report, check this box on the Filters page. You will then be prompted to alter the filters each time the report is run.
If you want to exclude the person by making them inactive across all reports, reference the "Managing Personnel" article.